食品伙伴網(wǎng)訊  2020年5月27日，歐盟食品安全局發(fā)布關于一種食品酶溶血磷脂酶（lysophospholipase）安全性的評估結果。

 

　　據(jù)了解，這種食品酶是由Novozymes A/S公司用轉基因黑曲霉（Aspergillus niger）菌株NZYM‐LP生產(chǎn)的。這種酶旨在用于生產(chǎn)葡萄糖糖漿的淀粉加工中。經(jīng)過評估，專家小組得出結論，這種食品酶在預期使用條件下不會引起安全問題。部分原文報道如下：

 

　　The genetic modifications do not give rise to safety concerns. The food enzyme is free from viable cells of the production organism and its DNA . The lysophospholipase food enzyme is intended to be used in starch processing for glucose syrups production, and for degumming of fats and oils. Residual amounts of total organic solids （TOS ） are removed by the purification steps applied during the production of glucose syrups, and washing and purification steps applied during degumming, consequently, dietary exposure estimation was considered not necessary. Genotoxicity tests did not raise safety concerns. The repeated dose 90‐day oral toxicity study was carried out with a phospholipase A1 from A. niger （strain NZYM ‐FP ）。 The Panel considered this enzyme as a suitable substitute to be used in this toxicity study in rats, because they derive from the same recipient strain, the location of the inserts are comparable, no partial inserts were present and the production methods are essentially the same. The Panel identified a no observed adverse effect level （NOAEL ） at the highest dose tested of 1,356 mg TOS /kg body weight （bw） per day. Similarity of the amino acid sequence to those of known allergens was searched and no match was found. The Panel considered that, under the intended conditions of use, the risk of allergic sensitisation and elicitation reactions by dietary exposure cannot be excluded, but the likelihood for this occurring is considered to be low. based on the data provided, the removal of TOS during the starch processing for the production of glucose syrups and during the degumming of fats and oils, the Panel concluded that this food enzyme does not give rise to safety concerns under the intended conditions of use.

 

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