食品伙伴網(wǎng)訊  據(jù)歐盟食品安全局（EFSA）消息，2019年10月18日，歐盟食品安全局就來自轉基因里氏木霉菌株DP‐Nzc36的纖維素酶（cellulase）的安全性評價發(fā)布意見。

 

　　據(jù)了解，這種纖維素酶旨在用于蒸餾酒精生產(chǎn)、生產(chǎn)葡萄糖漿的淀粉加工和釀造過程中。經(jīng)過評估，評估小組認為在預期使用條件下這種食品酶不會引起安全問題。

 

　　部分原文報道如下：

 

　　The food enzyme cellulase （4‐（1,3;1,4）‐beta‐D‐glucan 4‐glucanohydrolase; EC 3.2.1.4） is produced with the genetically modified Trichoderma reesei strain DP‐Nzc36 by Danisco US Inc. The genetic modifications do not give rise to safety concerns. The food enzyme is free from viable cells of the production organism and recombinant DNA. The food enzyme is intended to be used in distilled alcohol production, starch processing for the production of glucose syrups and brewing processes. Since residual amounts of the food enzyme are removed by distillation and starch processing, no dietary exposure was calculated for these food processes. based on the maximum use levels recommended for brewing processes and individual data from the EFSA Comprehensive European Food Database, dietary exposure to the food enzyme‐total organic solids （TOS） was estimated to be up to 0.131 mg TOS/kg body weight （bw） per day. Genotoxicity tests did not raise a safety concern. The systemic toxicity was assessed by means of a repeated dose 90‐day oral toxicity study in rats. The Panel identified a no observed adverse effect level of at least 97.6 mg TOS/kg bw per day which, compared to the estimated dietary exposure, results in a margin of exposure of at least 745.

 

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