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    當(dāng)前位置: 首頁(yè) » 食品資訊 » 外訊導(dǎo)讀 » 歐盟評(píng)估一種葡聚糖1,4-α-葡萄糖苷酶的安全性

    歐盟評(píng)估一種葡聚糖1,4-α-葡萄糖苷酶的安全性

    放大字體  縮小字體 時(shí)間:2022-07-01 10:30 來(lái)源:食品伙伴網(wǎng) 作者: 澤夕   
    核心提示:2022年6月30日,歐盟食品安全局就一種葡聚糖1,4-α-葡萄糖苷酶(glucan 1,4-α-glucosidase )的安全性評(píng)價(jià)發(fā)布意見(jiàn)。
       食品伙伴網(wǎng)訊  2022年6月30日,歐盟食品安全局就一種葡聚糖1,4-α-葡萄糖苷酶(glucan 1,4-α-glucosidase )的安全性評(píng)價(jià)發(fā)布意見(jiàn)。
     
      據(jù)了解,這種食品酶是由轉(zhuǎn)基因黑曲霉菌株NZYM-BE生產(chǎn)的,旨在用于生產(chǎn)葡萄糖漿和其他淀粉水解產(chǎn)物的淀粉加工、蒸餾酒精生產(chǎn)、釀造工藝、烘焙工藝、基于谷物的工藝以及用于果汁生產(chǎn)的水果和蔬菜加工。
     
      經(jīng)過(guò)評(píng)估,專家小組認(rèn)為,在預(yù)期的使用條件下(蒸餾酒精生產(chǎn)除外),不能排除飲食暴露引起過(guò)敏和誘發(fā)反應(yīng)的風(fēng)險(xiǎn),但這種情況發(fā)生的可能性很低。根據(jù)所提供的數(shù)據(jù),小組得出結(jié)論,該食品酶在預(yù)期的使用條件下不會(huì)引起安全隱患。部分原文報(bào)道如下:
     
      The food enzyme glucan 1,4-α-glucosidase (4-α-d-glucan glucohydrolase EC 3.2.1.3) is produced with the genetically modified Aspergillus niger strain NZYM-BE by Novozymes A/S. The genetic modifications do not give rise to safety concerns. The food enzyme was free from viable cells of the production organism and its DNA. The food enzyme is intended to be used in six food manufacturing processes, namely starch processing for the production of glucose syrups and other starch hydrolysates, distilled alcohol production, brewing processes, baking processes, cereal-based processes, and fruit and vegetable processing for juice production. Since residual amounts of total organic solids (TOS) are removed by distillation and by the purification steps applied to produce glucose syrups, dietary exposure was not calculated for these two food processes. For the remaining four processes, dietary exposure to the food enzyme–TOS was estimated to be up to 7.7 mg TOS/kg body weight (bw) per day in European populations. Genotoxicity tests did not raise a safety concern. The systemic toxicity was assessed by means of a repeated dose 90-day oral toxicity study in rats. The Panel identified a no observed adverse effect level of 3,795 mg TOS/kg bw per day, the highest dose tested, which when compared with the estimated dietary exposure, results in a margin of exposure above 490. Similarity of the amino acid sequence of the food enzyme to those of known allergens was searched for and one match found. The Panel considered that, under the intended conditions of use (other than distilled alcohol production) the risk of allergic sensitisation and elicitation reactions by dietary exposure cannot be excluded, but the likelihood for this to occur is considered to be low. based on the data provided, the Panel concluded that this food enzyme does not give rise to safety concerns under the intended conditions of use.
     
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    日期:2022-07-01
     
     
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