據(jù)了解，這種食品酶是由轉(zhuǎn)基因枯草芽孢桿菌菌株BABSC生產(chǎn)的，旨在用于烘焙工藝和淀粉加工以生產(chǎn)葡萄糖漿和其他淀粉水解產(chǎn)物。

 

　　經(jīng)過評估，專家小組認為，在預(yù)期的使用條件下，不能排除飲食暴露引起過敏和誘發(fā)反應(yīng)的風(fēng)險，但這種情況發(fā)生的可能性很低。由于缺乏充分描述生產(chǎn)菌株的適當(dāng)數(shù)據(jù)，專家小組無法就該食品酶在預(yù)期使用條件下的安全性得出結(jié)論。部分原文報道如下：

 

　　The food enzyme glucan 1,4-α-maltohydrolase (4-α-d-glucan α-maltohydrolase, EC 3.2.1.133) is produced with the genetically modified Bacillus subtilis strain BABSC by Advanced Enzyme Technologies Ltd. The requirements for the qualified presumption of safety (QPS) approach have not been met. The food enzyme is free from viable cells of the production organism and its DNA. It is intended to be used in baking processes and starch processing for the production of glucose syrups and other starch hydrolysates. Since residual amounts of total organic solids (TOS) are removed, dietary exposure was not calculated for starch processing for the production of glucose syrups and other starch hydrolysates. For baking processes, the dietary exposure was estimated to be up to 0.101 mg TOS/kg body weight per day in European populations. No toxicological studies were provided by the applicant. A search for the similarity of the amino acid sequence of the food enzyme to known allergens was made and one match with a respiratory allergen was found. The Panel considered that the risk of allergic reactions by dietary exposure cannot be excluded, but the likelihood is low. In the absence of appropriate data to fully characterise the production strain, the Panel was unable to conclude on the safety of the food enzyme under the intended conditions of use.

 

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