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    當(dāng)前位置: 首頁(yè) » 食品資訊 » 外訊導(dǎo)讀 » 歐盟評(píng)估轉(zhuǎn)基因地衣芽孢桿菌菌株NZYM-SD生產(chǎn)的葡聚糖1,4-α-麥芽水解酶...

    歐盟評(píng)估轉(zhuǎn)基因地衣芽孢桿菌菌株NZYM-SD生產(chǎn)的葡聚糖1,4-α-麥芽水解酶的安全性

    放大字體  縮小字體 時(shí)間:2022-06-16 14:40 來(lái)源:食品伙伴網(wǎng) 作者: 澤夕   
    核心提示:2022年6月15日,歐盟食品安全局就一種葡聚糖1,4-α-麥芽水解酶(glucan 1,4-α-maltohydrolas)的安全性評(píng)價(jià)發(fā)布意見(jiàn)。
       食品伙伴網(wǎng)訊  2022年6月15日,歐盟食品安全局就一種葡聚糖1,4-α-麥芽水解酶(glucan 1,4-α-maltohydrolas)的安全性評(píng)價(jià)發(fā)布意見(jiàn)。
     
      據(jù)了解,這種食品酶是由轉(zhuǎn)基因地衣芽孢桿菌菌株NZYM-SD生產(chǎn)的,旨在用于烘焙過(guò)程、釀造過(guò)程和淀粉加工,以生產(chǎn)葡萄糖漿和其他淀粉水解產(chǎn)物。
     
      經(jīng)過(guò)評(píng)估,專家小組認(rèn)為,在預(yù)期的使用條件下,不能排除飲食暴露引起過(guò)敏和誘發(fā)反應(yīng)的風(fēng)險(xiǎn),但這種情況發(fā)生的可能性很低。根據(jù)所提供的數(shù)據(jù),評(píng)估小組得出結(jié)論,這種食品酶在預(yù)期使用條件下不會(huì)引起安全問(wèn)題。部分原文報(bào)道如下:
     
      The food enzyme glucan 1,4-α-maltohydrolase (4-α-d-glucan α-maltohydrolase; 3.2.1.133) is produced with the genetically modified Bacillus licheniformis strain NZYM-SD by Novozymes A/S. The genetic modifications did not give rise to safety concerns. The production strain has been shown to qualify for Qualified Presumption of Safety (QPS) status. The food enzyme is free from viable cells of the production organism and its DNA. The food enzyme is intended to be used in three food manufacturing processes, namely baking processes and brewing processes and starch processing for glucose syrup production and other starch hydrolysates. Since residual amounts of total organic solids (TOS) are removed by the purification steps applied during the production of glucose syrups, dietary exposure was calculated only for baking and brewing processes. Dietary exposure was estimated to be up to 0.57 mg TOS/kg body weight (bw) per day in European populations. Given the QPS status of the production strain and the lack of hazards resulting from the food enzyme manufacturing process, toxicological studies were not considered necessary. Similarity of the amino acid sequence to those of known allergens was searched and four matches were found. The Panel considered that, under the intended conditions of use, the risk of allergic sensitisation and elicitation reactions upon dietary exposure to this food enzyme cannot be excluded, but the likelihood of such reactions to occur is considered to be low. based on the data provided, the QPS status of the production strain and the absence of issues arising from the production process, the Panel concluded that the food enzyme glucan 1,4-α-maltohydrolase produced with the genetically modified B. licheniformis strain NZYM-SD does not give rise to safety concerns under the intended conditions of use.
     
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    日期:2022-06-16
     
     
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