β-環(huán)糊精由7個(gè) α-1,4-鏈接 d-葡糖基構(gòu)成的環(huán)狀寡糖。在1996年歐盟專家組將其ADI定為5mg/kg體重/天。歐盟專家組經(jīng)過再次評(píng)估后認(rèn)為，ADI設(shè)定為5mg/kg體重/天仍然合理。然而在現(xiàn)有報(bào)道以及使用量的情況下，在品牌忠誠(chéng)的情況下，所有人群的攝入量會(huì)超過ADI數(shù)值，嬰兒平均值統(tǒng)計(jì)（mean percentile）以及所有人群95值統(tǒng)計(jì)（95th percentile）的情況除外。

 

    部分原文報(bào)道如下：

 

    he EFSA Panel on Food Additives and Nutrient Sources added to Food （ANS） provides a scientific opinion re-evaluating the safety of β-cyclodextrin （E 459） as a food additive. β-Cyclodextrin is a non-reducing cyclic oligosaccharide consisting of seven α-1,4-linked d-glucopyranosyl units. The Scientific Committee on Food （SCF） allocated an acceptable daily intake （ADI） of 5 mg/kg body weight （bw） per day to β-cyclodextrin （E 459） in 1996.

 

    The Panel concluded that, based on the available toxicological database, there is no reason to revise the current ADI of 5 mg/kg bw per day for β-cyclodextrin. based on the available reported use and use levels, the Panel also concluded that the ADI was exceeded in the refined brand-loyal scenario （considered the most relevant scenario） in all population groups except for infants at the mean and in all population groups at the 95th percentile.

 

    原文鏈接：http://onlinelibrary.wiley.com/doi/10.2903/j.efsa.2016.4628/full