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    當(dāng)前位置: 首頁(yè) » 食品資訊 » 外訊導(dǎo)讀 » 歐盟評(píng)估轉(zhuǎn)基因解淀粉芽孢桿菌菌株MAS生產(chǎn)的4-α-葡聚糖轉(zhuǎn)移酶的安全性

    歐盟評(píng)估轉(zhuǎn)基因解淀粉芽孢桿菌菌株MAS生產(chǎn)的4-α-葡聚糖轉(zhuǎn)移酶的安全性

    放大字體  縮小字體 時(shí)間:2025-05-20 10:26 來(lái)源:食品伙伴網(wǎng) 作者: 澤夕   
    核心提示:2025年5月19日,歐盟食品安全局就一種4-α-葡聚糖轉(zhuǎn)移酶(4-α-glucanotransferase)的安全性評(píng)價(jià)發(fā)布意見(jiàn)。
       食品伙伴網(wǎng)訊  2025年5月19日,歐盟食品安全局就一種4-α-葡聚糖轉(zhuǎn)移酶(4-α-glucanotransferase)的安全性評(píng)價(jià)發(fā)布意見(jiàn)。
     
      據(jù)了解,這種食品酶是由轉(zhuǎn)基因淀粉芽孢桿菌菌株MAS生產(chǎn)的,旨在用于生產(chǎn)酶處理的淀粉。
     
      經(jīng)過(guò)評(píng)估,專家小組認(rèn)為,在預(yù)期的使用條件下,不能排除飲食暴露引起過(guò)敏反應(yīng)的風(fēng)險(xiǎn),但這種情況發(fā)生的可能性很低。根據(jù)所提供的數(shù)據(jù),評(píng)估小組得出結(jié)論,這種食品酶在預(yù)期使用條件下不會(huì)引起安全問(wèn)題。部分原文報(bào)道如下:
     
      The food enzyme 4-α-glucanotransferase (1,4-α-d-glucan:1,4-α-d-glucan 4-α-d-glycosyltransferase; EC2.4.1.25) is produced with the genetically modified Bacillus amyloliquefaciens strain MAS by Koninklijke Cooperatie Avebe U.A. The production strain contains multiple copies of known antimicrobial resistance genes. However, based on the absence of viable cells and DNA from the production organism in the food enzyme, this is not considered to be a risk. The food enzyme is intended to be used in the production of enzymatically treated starch. Dietary exposure to the food enzyme total organic solids (TOS) was estimated to be up to 0.012 mg TOS/kg body weight (bw) per day in European populations. Genotoxicity tests did not indicate a safety concern. The systemic toxicity was assessed by means of a repeated dose 90-day oral toxicity study in rats. The Panel identified a no observed adverse effect level of 1000 mg TOS/kg bw per day, the highest dose tested, which when compared with the estimated dietary exposure, resulted in a margin of exposure of at least 83,333. A search for homology of the amino acid sequence of the 4-α-glucanotransferase to known allergens was made and no match was found. The Panel considered that a risk of allergic reactions upon dietary exposure cannot be excluded, but that the likelihood is low. based on the data provided, the Panel concluded that this food enzyme does not give rise to safety concerns, under the intended conditions of use.
     
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    日期:2025-05-20
     
     
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