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    歐盟評估轉基因里氏木霉菌株DP-Nyq99生產的?脯氨酰寡肽酶的安全性
    日期:2025-05-08  來源:食品伙伴網
       食品伙伴網訊  2025年5月7日,歐盟食品安全局就一種食品酶‌脯氨酰寡肽酶(prolyl oligopeptidase)的安全性評價發(fā)布意見。
     
      據了解,這種食品酶是由轉基因里氏木霉菌株DP-Nyq99生產的,旨在用于谷物和其他谷物的加工,以生產釀造產品。
     
      經過評估,專家小組認為,在預期的使用條件下,不能排除通過飲食接觸引起過敏反應的風險,但這種情況發(fā)生的可能性很低。根據所提供的數據,小組得出結論,該食品酶在預期的使用條件下不會引起安全問題。部分原文報道如下:
     
      The food enzyme prolyl oligopeptidase (EC 3.24.21.26) is produced with the genetically modified Trichoderma reesei strain DP-Nyq99 by Genencor international B.V. The genetic modifications do not give rise to safety concerns. The food enzyme was considered free from viable cells of the production organism and its DNA. The food enzyme is intended to be used in the processing of cereals and other grains for the production of brewed products. Dietary exposure was estimated to be up to 0.041 mg TOS/kg body weight (bw) per day in European populations. Genotoxicity tests did not indicate a safety concern. The systemic toxicity was assessed by means of a repeated dose 90-day oral toxicity study in rats. The Panel identified a no observed adverse effect level of 1000 mg TOS/kg body weight (bw) per day, the highest dose tested, which when compared with the estimated dietary exposure, results in a margin of exposure of at least 24,390. A search for the homology of the amino acid sequence of the prolyl oligopeptidase to known allergens was made and no match was found. The Panel considered that a risk of allergic reactions upon dietary exposure to the food enzyme cannot be excluded, but that the likelihood is low. based on the data provided, the Panel concluded that this food enzyme does not give rise to safety concerns under the intended conditions of use.
     
      本文由食品伙伴網食品資訊中心編輯,供網友參考,有任何疑問,請聯系news@foodmate.net。
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