據(jù)了解，這種食品酶是由非轉(zhuǎn)基因塔賓曲霉菌株MUCL 55013生產(chǎn)的，旨在用于10種食品生產(chǎn)過程：加工水果和蔬菜以生產(chǎn)果汁、其他水果和蔬菜產(chǎn)品、葡萄酒、葡萄酒蒸餾酒、除葡萄酒以外的酒精飲料；用于生產(chǎn)精制糖和未精制糖、植物食用油、脫脂生咖啡豆、咖啡提取物和茶以及其他草藥和水果浸劑的植物衍生產(chǎn)品加工。

 

　　經(jīng)過評估，專家小組認為，在預期的使用條件下，不能排除通過飲食接觸引起過敏反應(yīng)的風險，特別是對木瓜過敏的人，但這種風險不會超過食用木瓜的風險。根據(jù)所提供的數(shù)據(jù)，小組得出結(jié)論，這種食品酶在預期使用條件下不會引起安全問題。部分原文報道如下：

 

　　The food enzyme endo-polygalacturonase ((1→4)-α-D-galacturonan glycanohydrolase (endo-cleaving); EC 3.2.1.15)) is produced with the non-genetically modified Aspergillus tubingensis strain MUCL 55013 by Soufflet Biotechnologies. The food enzyme is free from viable cells of the production organism. It is intended to be used in 10 food manufacturing processes: processing of fruits and vegetables for the production of juices, other fruit and vegetable products, wine, distilled spirits from wine, alcoholic beverages other than grape wine; processing of plant-derived products for the production of refined and unrefined sugar, edible oils from plants, green coffee beans by demucilation, coffee extracts and tea and other herbal and fruit infusions. Since residual amounts of total organic solids (TOS) are removed in three processes, dietary exposure was calculated only for the remaining seven food manufacturing processes. Exposure was estimated to be up to 7.834 mg TOS/kg body weight (bw) per day in European populations. Genotoxicity tests did not indicate a safety concern. The systemic toxicity was assessed by a repeated dose 90-day oral toxicity study in rats. The Panel identified a no observed adverse effect level of 2,097 mg TOS/kg bw per day, the highest dose tested, resulting in a margin of exposure of at least 268. A search for the similarity of the amino acid sequence of the food enzyme to known allergens found 14 matches, one of which was to a food allergen. The Panel considered that the risk of allergic reactions upon dietary exposure to this food enzyme cannot be excluded, in particular for individuals sensitised to papaya, but that the risk will not exceed that of consumption of papaya. In addition, oral allergy reactions cannot be excluded in pollen-sensitised individuals. based on the data provided, the Panel concluded that this food enzyme does not give rise to safety concerns, under the intended conditions of use.

 

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