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    歐盟評(píng)估非轉(zhuǎn)基因黑曲霉菌株AGME 1415生產(chǎn)的葡聚糖1,4-α-葡萄糖苷酶的安全性
    日期:2025-04-09  來源:食品伙伴網(wǎng)
       食品伙伴網(wǎng)訊  2025年4月8日,歐盟食品安全局就一種葡聚糖1,4-α-葡萄糖苷酶(glucan-1,4-α-glucosidase)的安全性評(píng)價(jià)發(fā)布意見。
     
      據(jù)了解,這種食品酶是由非轉(zhuǎn)基因黑曲霉菌株AGME 1415生產(chǎn)的,旨在用于7種食品生產(chǎn)過程。
     
      經(jīng)過評(píng)估,專家小組認(rèn)為,在預(yù)期的使用條件下,不能排除飲食暴露引起過敏反應(yīng)的風(fēng)險(xiǎn),但這種情況發(fā)生的可能性很低。根據(jù)所提供的數(shù)據(jù),評(píng)估小組得出結(jié)論,這種食品酶在預(yù)期使用條件下不會(huì)引起安全問題。部分原文報(bào)道如下:
     
      The food enzyme glucan 1,4-α-glucosidase (4-α-d-glucan α-glucohydrolase; EC 3.2.1.3) is produced with the non-genetically modified Aspergillus niger strain AGME 1415 by ENMEX SA de CV, a Kerry Company. The food enzyme was considered free from viable cells of the production organism. It is intended to be used in seven food manufacturing processes. Since residual amounts of food enzyme-total organic solids (TOS) are removed in two food manufacturing processes, dietary exposure was calculated only for the remaining five processes. It was estimated to be up to 7.143 mg TOS/kg body weight per day in European populations. Genotoxicity tests did not indicate a safety concern. The systemic toxicity was assessed by means of a repeated dose 90-day oral toxicity study in rats. The Panel identified a no observed adverse effect level of 2000 mg TOS/kg body weight (bw) per day, the highest dose tested, which when compared with the estimated dietary exposure, resulted in a margin of exposure of at least 280. A search for the homology of the amino acid sequence of the glucan 1,4-α-glucosidase to known allergens was made and one match with a respiratory allergen was found. The Panel considered that a risk of allergic reactions by dietary exposure to the food enzyme cannot be excluded, but that the likelihood is low. based on the data provided, the Panel concluded that this food enzyme does not give rise to safety concerns, under the intended conditions of use.
     
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