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    歐盟評估轉(zhuǎn)基因地衣芽孢桿菌菌株NZYM-JQ生產(chǎn)的谷氨酰胺酶的安全性
    日期:2024-04-15  來源:食品伙伴網(wǎng)
       食品伙伴網(wǎng)訊  2024年4月12日,歐盟食品安全局就一種谷氨酰胺酶(glutaminase)的安全性評價發(fā)布意見。
     
      據(jù)了解,這種食品酶是由轉(zhuǎn)基因地衣芽孢桿菌菌株NZYM-JQ生產(chǎn)的,旨在用于六種食品生產(chǎn)過程。
     
      經(jīng)過評估,專家小組認為,在預(yù)期的使用條件下,不能排除飲食暴露引起過敏反應(yīng)的風(fēng)險,特別是對樺樹和橡樹花粉過敏的個體。根據(jù)所提供的數(shù)據(jù),評估小組得出結(jié)論,這種食品酶在預(yù)期使用條件下不會引起安全問題。部分原文報道如下:
     
      The food enzyme glutaminase (l-glutamine amidohydrolase EC 3.5.1.2) is produced with the genetically modified Bacillus licheniformis strain NZYM-JQ by Novozymes A/S. The genetic modifications do not give rise to safety concerns. The production strain met the requirements for the qualified presumption of safety (QPS). The food enzyme is free from viable cells of the production organism and its DNA. The enzyme under assessment is intended to be used in six food manufacturing processes. Dietary exposure was estimated to be up to 0.148 mg TOS/kg body weight per day in European populations. Given the QPS status of the production strain and the absence of concern resulting from the food enzyme manufacturing process, toxicological studies were not considered necessary. A search was made for the similarity of the amino acid sequence to those of known allergens and one match with a pollen allergen was found. The Panel considered that the risk of allergic reactions by dietary exposure cannot be excluded, particularly for individuals sensitised to birch and oak pollen. The Panel concluded that the food enzyme does not give rise to safety concerns under the intended conditions of use.
     
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